Table 3.
Cytokine-inducible DUBs and their effects.
| DUB | Cytokine | Effects (cell line/organism) | References |
|---|---|---|---|
| DUB-1 | IL-3 | increases (Ba/F3) | [85] |
| IL-5 | increases (Ba/F3) | [87] | |
| GM-CSF | |||
| DUB-1A | IL-3 | increases (Ba/F3) | [88] |
| DUB-2 | IL-2 | increases (CTLL) | [89] |
| DUB-2A | CSF3 | increases (myeloid 32D) | [92] |
| DUB-2A | IL-4 | increases (Raji) | [94] |
| IL-6 | increases (U937) | [94] | |
| Otud-6B | IL-3 | increases (Ba/F3) | [96] |
| IL-4 | |||
| IL-13 | |||
| GM-CSF | |||
| USP18 | IFN-β | increases (THP-1, THP-1 derived macrophage) | [42] |
| USP48 | TNFα | + (beas2B) | [71] |
| A20 | TNFα | increases (HUVEC) | [98] |
| Cezanne | TNFα | increases (HEK293, HUVEC) | [68] |
Increase = inc. in production.
+ = induce positive effect.