Table 6.
Best overall response for all dose groups of panobinostat (PAN).
| Best response | PAN 15 mg N =11 n (%) | PAN 20 mg N= 15 n (%) | PAN 25 mg N= 8 n (%) | PAN 20 mg (expansion phase) N= 12 n (%) | All patients N =46 n (%) |
|---|---|---|---|---|---|
| Response rate (CR or CRi) | 9 (81.8) | 9 (60.0) | 4 (50.0) | 6 (50.0) | 28 (60.9) |
| 95% confidence interval1 | [48.2, 97.7] | [32.3, 83.7] | [15.7, 84.3] | [21.1, 78.9] | [45.4, 74.9] |
| Complete remission (CR) | 6 (54.5) | 7 (46.7) | 2 (25.0) | 5 (41.7) | 20 (43.5) |
| Complete remission with incomplete blood count recovery (CRi) | 3 (27.3) | 2 (13.3) | 2 (25.0) | 1 (8.3) | 8 (17.4) |
| Partial remission (PR) | 0 (0.0) | 0 (0.0) | 1 (12.5) | 1 (8.3) | 2 (4.3) |
| Treatment failure | 1 (9.1) | 6 (40.0) | 3 (37.5) | 3 (25.0) | 13 (28.3) |
| Unknown | 1 (9.1) | 0 (0.0) | 0 (0.0) | 2 (16.7) | 3 (6.5) |
1
Exact 95% confidence interval (Clopper Pearson) for percentage.