Table 2.
Performance characteristics of all three assays by virus type
| Virus | CC |
R-mix™ |
DAT |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of detected/TPa | Sensitivity (95% CI) (%) | NPVb (%) | Mean TTDc | No. of detected/TP | Sensitivity (95% CI) (%) | NPV (%) | Mean TTD | No. of detected/TP | Sensitivity (95% CI) (%) | NPV (%) | Mean TTD | |
| RSV | 33/78 | 42 (32–53%) | 91.5 | 8.0 | 57/78 | 73 (62–82%) | 95.8 | 1.2 | 72/72d | 100 (94–100%) | 100 | <1.0 |
| Influenza A and B | 27/36 | 75 (59–86%) | 98.3 | 3.4 | 28/36 | 78 (62–89%) | 98.5 | 1.1 | 15/23d | 65 (45–81%) | 98.5 | <1.0 |
| Adenovirus | 31/31 | 100 (87–100%) | 100 | 4.8 | 14/31 | 45 (29–62%) | 96.9 | 1.4 | – | – | – | – |
| Parainfluenza 1–3 | 20/23 | 87 (67–96%) | 99.4 | 6.0 | 19/23 | 83 (62–94%) | 99.2 | 1.2 | – | – | – | – |
| Enterovirus/rhinovirus | 23/23 | 100 (83–100%) | n.d.e | n.d. | – | – | – | – | – | – | – | – |
| CMV | 11/11 | 100 (70–100%) | n.d. | n.d. | – | – | – | – | – | – | – | – |
| HSV | 5/5 | 100 (51–100%) | n.d. | n.d. | – | – | – | – | – | – | – | – |
True positives defined as positive results by any methodology (specificity and PPV = 100%).
a
True positives.
b
Negative predictive value.
c
Time to detection (days) = duration between completion of sample processing and issuance of test result.
d
Lower denominators for DAT compared to cultures reflect fewer samples tested by this methodology.
e
Not determined.