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. 2004 Jul 28;7(4):412–419. doi: 10.1016/j.mib.2004.06.007

Figure 2.

Figure 2

Overview of the domain organization and proteolytic processing of SARS-CoV replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa). The processing end-products of pp1a are designated nonstructural proteins (nsp) 1 to nsp11 and those of pp1ab are designated nsp1 to nsp10 and nsp12 to nsp16. Cleavage sites that are predicted to be processed by the viral main protease, 3CLpro, are indicated by grey arrowheads, and sites that are processed by the papain-like protease, PL2pro, are indicated by black arrowheads. For further details on SARS-CoV replicative proteins, see Table 1. ADRP, ADP-ribose 1″-phosphatase; PL2pro, papain-like protease 2; 3CLpro, 3C-like main protease; RdRp, RNA-dependent RNA polymerase; TM1, TM2, TM3, transmembrane domains 1, 2 and 3; C/H, domains containing conserved Cys and His residues.