Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Dec 1;148(12):5943–5954. doi: 10.1210/en.2007-0850

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007 by The Endocrine Society

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Fig. 4. — Milk calcium concentrations are reduced in PMCA2 mutant mice. A, On d 12 of lactation, milk calcium concentrations were approximately 70% lower (P < 0.01) in dfw-2J/dfw-2J mice (n = 4) than in BALB/c controls (n = 7). B, Milk from dfw/dfw mice (n = 4) had 30% less calcium (P < 0.05) than did milk from C3H controls (n = 5). In both cases, the heterozygous mice (dfw/+, n = 6; dfw-2J/+, n = 4) had milk calcium concentrations between the wild-type and homozygous mutant mice (A and B) but were not significantly different from wild-type mice. Milk protein levels (C and D) were also reduced in the dfw-2J/dfw-2J but not the dfw/dfw mutant mice (P < 0.01). Because most milk calcium is bound to proteins (mainly caseins), the milk calcium concentration was corrected for differences in protein content (E and F). Even when corrected for protein content, milk calcium levels were significantly reduced in dfw-2J/dfw-2J (P < 0.01) and dfw/dfw (P < 0.05) mutant mice. Statistical significance is represented with an asterisk.