Figure 1.

Amiodarone and analogues. (a) Amiodarone structural determinants: benzofuran moiety with butyl lateral group (I), diiodobenzoyl moiety (II) and diethylamino-β-ethoxy moiety with tertiary nitrogen atom (III). (b) Analogues listed in order of decreasing hydrophobicity; + or − indicate the ability of inducing an NPC-like phenotype and of inhibiting GP-mediated viral entry at the concentrations used in this work (0.3 μM dronedarone, 0.3 μM DDEA, 0.3 μM B2-O-EtOH, 2 μM MDEA, all other 10 μM).