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HCV infection inhibits the TNF‐α induced NF‐κB activation. In HCV infections, the nonstructural proteins NS5A and NS5B have been implicated in activating the NF‐κB pathway. The mechanism by which NS5A and NS5B inhibit NF‐κB has not yet been determined and as such we have denoted a probable mechanism by dashed lines. However, HCV utilizes IKKα independent of the NF‐κB pathway at later stages of infection. HCV core protein associates with lipid droplets during viral assembly.
