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VEEV nsP3 interaction with IKKβ to activate the NF‐κB cascade. VEEV polyprotein processing results in nsP3 interacting with the IKKβ subunit of the IKK complex. It has yet to be determined whether this interaction is required for activation of the NF‐κB cascade and hence is denoted by dashed lines. The nsP3‐IKKβ interaction is required for VEEV replication in infected cells.
