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. 2010 May 10;19(14):2828–2840. doi: 10.1093/hmg/ddq183

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Figure 4. — Lifespan and behavioral rescue of fh-deficient Drosophila by GLaz overexpression. (A and D) Lifespan experiments under hyperoxia conditions (99.5% O₂) using either fhRNAi-1 (A) or fhRNAi-2 (D) flies. GLaz is able to partially protect frataxin-deficient Drosophila against oxidative insult although no benefit is detected in control flies. (B and E) Lifespan under standard conditions using fhRNAi-1 (B) or fhRNAi-2 (E) flies. Co-expression of GLaz shows an extension of mean and maximum lifespan of flies with reduced frataxin. (C and F) Negative geotaxis experiments of 5- and 10-day-old flies using fhRNAi-1 (C) or fhRNAi-2 (F) flies. GLaz alleviates the locomotor deficits in frataxin knock-down individuals. Survival curves were analyzed using the Kaplan–Meier test. Significance in (C) and (F) was determined by one-way ANOVA with post hoc Newman–Keuls (***P < 0.001). Error bar represents standard error.