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. 2010 May 10;19(14):2828–2840. doi: 10.1093/hmg/ddq183

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Figure 5. — GLaz decreases lipid peroxidation levels and restores aconitase activity in frataxin-deficient flies. (A) Frataxin-deficient adults (fhRNAi-2/+;da-GAL4/+) display an increase in lipid peroxides that can be restored to control levels by GLaz in 5-day-old flies (5d) but not in 15-day-old flies (15d). (B) fhRNAi-2/+;da-GAL4/+ do not induce any significant changes in TAG or FFA content. (C and D) GLaz significantly protects aconitase from ROS-mediated inactivation in frataxin-deficient L3 (caused by fhRNAi-1 transgene) and adult flies (caused by fhRNAi-2 transgene). Significance was determined by one-way ANOVA with post hoc Newman–Keuls (***P < 0.001). Error bar represents standard error. FFA, free fatty acid; TAG, triacylglycerides.