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Measurement of FSH, LH, E2, and E1 for the patient from the initial evaluation at age 15 years and 1 month to the most recent follow-up visit at age 23 years and 4 months. Note the persistent elevation of both gonadotropins and estrogens. Note the decrease in E2 with norethindrone treatment (red arrow). E1 was first measured at age 17 years and 4 months. Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone.
