Figure 1.

Initial neuroendocrine evaluation in a female patient with arhinia (No. 11) at age 16 years (before hormone replacement therapy) demonstrating undetectable gonadotropins but normal cortisol, prolactin, and growth hormone (GH) secretion, including normal sleep augmentation of GH. Estradiol was undetectable (<20 pg/ml). Medical records indicated the patient was also clinically and biochemically euthyroid. A second frequent sampling study performed at age 23 years again showed apulsatile luteinizing hormone secretion (data not shown). To convert cortisol (μg/dL) to nmol/L, multiply by 27.59.