Fig 3. Disease Ontology categories for the 136 diseases that showed overrepresentation of green module genes.

Boxes are colored according to the top-level disease categories and labels show the second-level categories. The size of each box is proportional to the number of disease terms in that category with significant overrepresentation of green module genes. Some disease terms belong to more than one category (e.g., multiple sclerosis is both a “nervous system disease” and an “immune system disease”), but each term is only represented once. For “disease of anatomical entity” terms, squares are shaded by the proportion of terms that represent autoimmune/inflammatory diseases (e.g., 3 of 16 “gastrointestinal system disease”terms are autoimmune/inflammatory, while 9 of 11 “immune system disease” terms are). The full list of disease terms, with (manually curated) autoimmune/inflammatory terms highlighted, is given in S3 File.