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. 2020 Mar 19;16(3):e1007969. doi: 10.1371/journal.ppat.1007969

Fig 11. K. pneumoniae T6SS mutants displayed reduced virulence in the G. mellonella infection model.

Fig 11

(A, B, C) Kaplan–Meier plots showing the per cent survival of G. mellonella over 120 h post-infection with 105 organisms of the following strains: Kp52145, 52145-ΔclpV (ΔclpV), 52145-ΔtssB (ΔtssB), 52145-ΔvgrG1 (ΔvgrG1), 52145-ΔvgrG2 (ΔvgrG2), 52145-ΔvgrG4 (ΔvgrG4), 52145-ΔvgrG2-ΔvgrG1 (ΔvgrG2-ΔvgrG1), 52145-ΔvgrG1-ΔvgrG4 (ΔvgrG1-ΔvgrG4), 52145-ΔvgrG2-ΔvgrG4 (ΔvgrG2-ΔvgrG4), 52145-ΔvgrG2- ΔvgrG1-ΔvgrG4 (ΔvgrG2- ΔvgrG1-ΔvgrG4). Thirty larvae were infected in each group. Level of significance was determined using the log-rank (Mantel–Cox) test with Bonferroni correction for multiple comparisons where applicable [a = (A) 0.0008; (B) 0.05]. P-values presented correspond to the difference between (A) Kp52145 and the other strains, (B) Kp52145 and 52145-ΔvgrG1 (ΔvgrG1), 52145-ΔvgrG2 (ΔvgrG2), (C) Kp52145 and the other strains.