Table 1.
Indices of GH Action in Targeted Cohort of IGSF1-Deficient Male Patients
| Patients | Reference Data Source and Range | P Value | |
|---|---|---|---|
| n | 21 | ||
| Age (y) | 55.1 (21.8–85.2) | ||
| BMI (kg/m2) | 27.4 (24.4–34.6) | ||
| Classified as acromegalic (%)a | 52.4 | 19.1b | 0.024 |
| Finger soft-tissue thickness (SDS)c | 1.1 (-0.3 to 2.3) | (9) | 0.001 |
| Adult height SDS | -0.4 (-1.7 to 1.0) | (10, 11) | 0.138 |
| Head circumference (SDS) | 1.3 (0.1–2.4) | (12) | <0.001 |
| Fat mass index (SDS)d | -0.08 (-0.94 to 4.95) | (13) | 0.175 |
| Fat free mass index (SDS)d | 0.40 (-2.42 to 1.92) | (13) | 0.793 |
| IGF-1 (SDS) | 1.0 (-0.1 to 2.9) | In-house (age-dependent) | 0.001 |
| Free T4 (pmol/L) | 14.3 (8.9–21.9) | 12.0–22.0 pmol/L | |
| Prolactin (µg/L) | 4.3 (1.4–15.4) | 4.0–15.0 µg/L | |
| Testosterone (nmol/L) | 14.3 (7.9–22.1) | 8.0–31.0 nmol/L | |
| Cortisol (µmol/L) | 0.355 (0.196–0.533) | 0.100–0.600 µmol/L | |
| Testicular volume (SDS)e | 2.9 (1.2–5.8) | (14) | <0.001 |
Data presented as number or median (P10-P90).
Abbreviations: BMI, body mass index; SDS, standard deviation score.
aBased on software analysis of facial photographs.
bBased on 18 in-house age- and BMI-matched controls.
cN = 20.
dCorrected for BMI and height, available n = 19 for fat mass index and n = 16 for fat-free mass index.
eUltrasonographic volume of largest testis, n = 16.