. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Addiction. 2019 Jul 30;114(10):1753–1762. doi: 10.1111/add.14712

Table 2.

Linear mixed models for alcohol related behaviors (n = 1201).

	Model 1				Model 2				Model 3
	b	95% CI			b	95% CI			b	95% CI
Drinking frequency
Female	−0.456	−0.572	−0.340	^***	−0.458	−0.574	−0.342	^***	−0.437	−0.606	−0.268	^***
In relationship	−0.090	−0.198	0.018		−0.087	−0.195	0.021		−0.069	−0.224	0.086
GPS	0.109	0.050	0.168	^***	0.169	0.085	0.253	^***	0.193	0.085	0.301	^**
In relationship × GPS	–	–	–		−0.105	−0.211	−0.001	^*	−0.158	−0.307	−0.009	^*
Female × GPS	–	–	–		–	–	–		−0.061	−0.230	0.108
Female × in relationship	–	–	–		–	–	–		−0.038	−0.254	0.178
Female × in	–	–	–		–	–	–		0.109	−0.107	0.325
relationship × GPS
Pseudo-R²	0.073				0.076				0.077
Intoxication frequency
Female	−0.543	−0.657	−0.429	^***	−0.544	−0.658	−0.430	^***	−0.535	−0.700	−0.370	^***
In relationship	−0.178	−0.284	−0.072	^**	−0.176	−0.282	−0.070	^**	−0.171	−0.322	−0.020	^*
GPS	0.111	0.054	0.168	^***	0.179	0.097	0.261	^***	0.239	0.133	0.345	^***
In relationship × GPS	–	–	–		−0.118	−0.220	−0.016	^*	−0.222	−0.365	−0.079	^**
Female × GPS	–	–	–		–	–	–		−0.149	−0.314	0.016
Female × in relationship	–	–	–		–	–	–		−0.016	−0.226	0.194
Female × in	–	–	–		–	–	–		0.223	0.013	0.433	^*
relationship × GPS
Pseudo-R²	0.110				0.114				0.117
AD symptoms
Female	−0.197	−0.317	−0.077	^**	−0.199	−0.319	−0.079	^**	−0.123	−0.297	0.051
In relationship	−0.097	−0.209	0.015		−0.095	−0.207	0.017		−0.028	−0.189	0.133
GPS	0.123	0.064	0.182	^***	0.191	0.105	0.277	^***	0.196	0.084	0.308	^**
In relationship × GPS	–	–	–		−0.119	−0.229	−0.009	^*	−0.154	−0.309	0.001
Female × GPS	–	–	–		–	–	–		−0.018	−0.192	0.156
Female × in relationship	–	–	–		–	–	–		−0.134	−0.359	0.091
Female × in	–	–	–		–	–	–		0.069	−0.154	0.292
relationship × GPS
Pseudo-R²	0.029				0.032				0.034

Linear mixed models for each of the alcohol phenotypes. Each model includes age, educational attainment, and student status as covariates. Clustering at the family level modeled by including random intercepts. GPS and alcohol phenotypes were standardized for easier interpretation.

P < 0.05

^**

P < 0.01;

^***

P < 0.001. GPS = genome-wide polygenic scores.