Both the top decile and top quintile are compared to the remainder of the sample. All estimates are adjusted for age, sex, systolic blood pressure, treatment for hypertension, prevalent diabetes, prevalent atrial fibrillation, prevalent cardiovascular disease, total cholesterol, high-density lipoprotein cholesterol, smoking status, body mass index, and positivity for an APOE ε4 allele. Estimates for the Cardiovascular Health Study (CHS) are further adjusted for race and clinic site. CI = confidence interval; FHS = Framingham Heart Study; HR = hazard ratio; SDU = SD increase.