Skip to main content
. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Nat Struct Mol Biol. 2019 Nov 18;26(12):1123–1131. doi: 10.1038/s41594-019-0330-y

Fig. 2. Cryo-EM structure of a β2V2R–Gs–βarr1 megaplex.

Fig. 2.

a, Composite cryo-EM density map of the megaplex reconstruction fitted into a transparent envelope of the megaplex consensus structure. b, Same as in a, but with protein stabilizers (Nb35, Nb32, and Fab30) and consensus reconstruction removed. Red dashed lines indicate the flexible C-terminal tail connecting βarr1 to the receptor.