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. 2020 Mar 16;130(4):2129–2145. doi: 10.1172/JCI132691

Figure 7. Loss of ESRP2 promotes adult-to-fetal switch in Gao binge model.

Figure 7

(A) qRT-PCR analysis for Esrp2 and YAP/TAZ target genes (Areg, Fgf1, Itgb2, and Birc5) in WT and Esrp2-KO mice exposed to 10 days feeding and 1 binge drinking of ethanol (10d + 1B) and pair-fed mice. (B) IHC for ESRP2 in liver sections from these mice. Scale bars: 100 μm. (C–D) Alternative splicing for HK mRNAs and EMT-related genes (Slk, Arhgef10l, Flnb, and Kras) in WT and Esrp2-KO Gao binge mouse models (C). See full, unedited gels in the supplemental material. All results are graphed as dot plots (WT pair, white circles; WT 10d + 1B, white squares; Esrp2-KO pair, black circles; Esrp2-KO 10d + 1B, black squares) showing mean ± SEM (red bars) (n = 3–7 individuals/group) (D). All statistical analyses were performed by 2-way ANOVA with Tukey’s corrections.