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. 2020 Mar 9;130(4):2001–2016. doi: 10.1172/JCI134699

Figure 4. β-Adrenergic activity in BAT mediates leptin’s effect of driving postprandial increases in body temperature.

Figure 4

(A and B) Plasma leptin and epinephrine concentrations in 24-hour-fasted sham-operated and ADX rats infused with low corticosterone by subcutaneous pump and given access to 2% sucrose drinking water. (C and D) Body temperature and heart rate. In A–D, ****P < 0.0001 between groups using 2-tailed unpaired Student’s t test. n = 8 per group. (E–G) Plasma leptin, epinephrine, and norepinephrine concentrations in 48-hour-fasted-refed and –leptin-infused sham-operated and BATectomized rats. (H) Body temperature. In E and H, comparisons with time 0 (asterisks above bars) were performed using 2-tailed paired Student’s t test and comparisons between groups performed using ANOVA with Bonferroni’s multiple-comparisons test: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. In all panels, data are presented as mean ± SEM. If no symbol appears, groups and time points are not statistically different.