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. 2020 Feb 24;130(4):1728–1742. doi: 10.1172/JCI131752

Figure 10. Working model of eCB/BLA/NAc interactions in Shank3B–/– mice.

Figure 10

Shank3B–/– mice exhibit increased sEPSC and sIPSC frequency onto MSNs in the NAc relative to WT mice and exhibit social impairment. In Shank3B–/– mice treated with systemic or intra-NAc JZL184 to increase 2-AG levels, sEPSC and sIPSC frequency is normalized as is BLA-NAc FF inhibition, resulting in a reduction in social deficits. Shank3B–/– mice with optogenetic inhibition of BLA-NAc circuit function are hypothesized to have similarly reduced FF inhibition and reduced overall glutamatergic drive to GABA interneurons and MSNs, which also reduces social deficits.