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. 2020 Mar 16;130(4):2041–2053. doi: 10.1172/JCI129635

Figure 3. Effects of CFTR inhibition or deletion on thrombin-induced platelet activation.

Figure 3

(A) Representative gating scheme of platelet activation (CD41+ events) quantifying CD62P expression with or without thrombin stimulation in WT or CFTR–/– platelets with or without CFTRinh-172 (CF172). (B) CD62P expression in platelets from WT, CFTR–/–, CFfl/fl, and CF-PF4 mice with or without thrombin stimulation plus vehicle or CFTRinh-172 (CF172). Data are mean ± SEM of 5 to 8 mice. Data were analyzed by 2-way ANOVA. *P ≤ 0.05; **P ≤ 0.01; ****P ≤ 0.0001.