Table 2.
Proportions by hand OA incidence definition over ~ 12 (±1.2) year follow-up for those without baseline hand OA, by sex or race
| Hand OA incidence definition | Overall (n=473) |
Women (n=309) |
Men (n=164) |
Women vs Men* | White (n=286) |
African American (n=187) |
White vs AA* |
|---|---|---|---|---|---|---|---|
| % or median (interquartile range: Q1-Q3) |
effect (95% CI) | % or median (interquartile range: Q1-Q3) |
effect (95% CI) | ||||
| Radiographic HOA (≥1 joint(s)) | 59.4% | 60.5% | 57.3% | 1.26 (0.84, 1.90) | 65.0% | 50.8% | 2.26 (1.49, 3.43) |
| DIP (2nd – 5th) OA | 32.1% | 34.0% | 28.7% | 1.60 (1.03, 2.49) | 40.2% | 19.8% | 3.16 (1.97, 5.07) |
| PIP (2nd – 5th) OA | 20.1% | 21.4% | 17.7% | 1.24 (0.82, 1.87) | 22.7% | 16.0% | 1.17 (0.77, 1.77) |
| Thumb IP OA | 24.5% | 24.9% | 23.8% | 1.02 (0.64, 1.61) | 23.1% | 26.7% | 0.87 (0.55, 1.37) |
| MCP (1st – 5th) OA | 13.5% | 11.7% | 17.1% | 0.59 (0.34, 1.04) | 13.6% | 13.4% | 1.08 (0.60, 1.95) |
| Thumb base OA | 20.7% | 22.3% | 17.7% | 1.59 (0.96, 2.64) | 24.1% | 15.5% | 2.11 (1.24, 3.58) |
| Radiographic HOA (≥2 joint(s)) | 31.7% | 33.0% | 29.3% | 1.18 (0.78, 1.79) | 35.3% | 26.2% | 1.60 (1.05, 2.45) |
| Symptomatic HOA (≥1 joint(s)) | 12.9% | 15.9% | 7.3% | 2.98 (1.50, 5.91) | 17.1% | 6.4% | 4.29 (2.08, 8.86) |
| Number of radiographic HOA joints | 1 (0-3) | 1 (0-3) | 1 (0-2) | 1.33 (1.03, 1.72)1 | 1 (0-3) | 1 (0-2) | 2.00 (1.54, 2.61)1 |
| Number of symptomatic HOA joints | 0 (0-0) | 0 (0-0) | 0 (0-0) | 4.74 (2.08, 10.8)1 | 0 (0-0) | 0 (0-0) | 1.69 (0.41, 7.06)1 |
| Max=93 | Max=9 | Max=2 | Max=9 | Max=3 | |||
| Total sum KL score (30 joints) | At T3: | At T3: | At T3: | 0.99 (0.95, 1.03)2 | At T3: | At T3: | 1.00 (0.96, 1.04)2 |
| 11 (7-19) | 12 (8-19) | 11 (7-18) | 12 (8-20) | 11 (7-16) | |||
| Δ T3-T1: | Δ T3-T1: | Δ T3-T1: | Δ T3-T1: | Δ T3-T1: | |||
| 7 (4-12) | 7 (4-12) | 8 (4-11) | 8 (5-14) | 6 (3-9) |
Distal interphalangeal joint (DIP), Hand osteoarthritis (HOA), Interphalangeal joint (IP), Kellgren-Lawrence grade (KLG), Metacarpophalangeal joint (MCP), Osteoarthritis (OA), Proximal interphalangeal joint (PIP); Δ=change from T1 to T3 (baseline to follow up)
Effects shown are adjusted for baseline: age, sex, race, education, BMI, and weight gain—additionally adjusted for HOA baseline values for total sum KL score.
Logit models for categorical definitions producing adjusted odds ratios (aOR)
zero inflated negative binomial models for continuous definitions producing adjusted incidence density ratios (aIDR)
scaled negative binomial model for continuous definitions producing adjusted incidence density ratios (aIDR)