Table 3.
Proportion by hand OA progression definition over ~ 12 (±1.2) year follow-up for those with baseline hand OA, by sex or race
| Hand OA progression definition |
Overall (n=327) |
Women (n=235) |
Men (n=92) |
Women vs Men* | White (n=262) |
African American (n=65) |
White vs AA* |
|---|---|---|---|---|---|---|---|
| % or median (interquartile range: Q1-Q3) |
effect (95% CI) | % or median (interquartile range: Q1-Q3) |
effect (95% CI) | ||||
| Radiographic HOA (additional in ≥1 joint(s)) | 94.2% | 94.0% | 94.6% | 0.70 (0.22, 2.22) | 95.4% | 89.2% | 1.15 (0.38, 3.45) |
| DIP (2nd – 5th) OA | n=306 | n=218 | n=88 | 1.26 (0.67, 2.37) | n=242 | n=64 | 1.39 (0.70, 2.76) |
| 77.8% | 79.4% | 73.9% | 81.0% | 65.6% | |||
| PIP (2nd – 5th) OA | n=318 | n=228 | n=90 | 1.38 (0.80, 2.37) | n=254 | n=64 | 0.94 (0.51, 1.76) |
| 63.5% | 66.2% | 56.7% | 65.0% | 57.8% | |||
| Thumb IP OA | n=286 | n=205 | n=81 | 0.80 (0.46, 1.37) | n=228 | n=58 | 1.30 (0.71, 2.40) |
| 56.3% | 54.2% | 61.7% | 57.9% | 50.0% | |||
| MCP (1st – 5th) OA | 44.0% | 38.7% | 57.6% | 0.61 (0.36, 1.05) | 44.7% | 41.5% | 0.96 (0.52, 1.77) |
| Thumb base OA | n=274 | n=193 | n=81 | 2.56 (1.44, 4.55) | n=215 | n=59 | 3.39 (1.74, 6.60) |
| 54.7% | 60.6% | 40.7% | 60.5% | 33.9% | |||
| Radiographic HOA (additional ≥2 joint(s)) | 80.4% | 81.3% | 78.3% | 1.11 (0.59, 2.10) | 82.4% | 72.3% | 1.08 (0.53, 2.18) |
| Symptomatic HOA (additional ≥1 joint(s)) | 31.0% | 31.9% | 28.6% | 1.25 (0.72, 2.16) | 32.4% | 25.0% | 1.96 (1.01, 3.83) |
| Number of radiographic HOA joints | At T3: | At T3: | At T3: | 1.17 (0.99, 1.39)1 | At T3: | At T3: | 1.12 (0.92, 1.36)1 |
| 9 (4-14) | 9 (5-15) | 8 (4-12) | 10 (5-15) | 6 (3-10) | |||
| ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | |||
| 5 (2-8) | 6 (3-9) | 5 (2-7) | 6 (3-8) | 4 (2-8) | |||
| Number of symptomatic HOA joints | At T3: | At T3: | At T3: | 0.23 (−0.34, 0.81)2 | At T3: | At T3: | 0.46 (−0.21, 1.12)2 |
| 0 (0-1) | 0 (0-2) | 0 (0-1) | 0 (0-1) | 0 (0-0) | |||
| ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | |||
| 0 (0-1) | 0 (0-1) | 0 (0-0) | 0 (0-1) | 0 (0-0) | |||
| Total sum KL score (30 joints) | At T3: | At T3: | At T3: | 1.09 (0.97, 1.24)1 | At T3: | At T3: | 1.09 (0.94, 1.26)1 |
| 34 (21-45) | 35 (22-47) | 32.5 (19-42) | 35 (23-47) | 27 (17-37) | |||
| ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | ΔT3-T1: | |||
| 16 (9-22) | 16 (10-23) | 14.5 (8.5-20.5) | 17 (10-22) | 13 (8-18) |
Distal interphalangeal joint (DIP), Hand osteoarthritis (HOA), Interphalangeal joint (IP), Kellgren-Lawrence grade (KLG), Metacarpophalangeal joint (MCP), Osteoarthritis (OA), Proximal interphalangeal joint (PIP); Δ=change from T1 to T3 (baseline to follow up)
Effects shown are adjusted for baseline: age, sex, race, education, BMI, weight gain, and HOA baseline values.
Logit models for categorical definitions producing adjusted odds ratios (aOR)
scaled negative binomial model for continuous definitions producing adjusted incidence density ratios (aIDR)
scaled regression models for the number of symptomatic HOA joints producing adjusted betas.