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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Cancer Lett. 2020 Feb 27;477:97–106. doi: 10.1016/j.canlet.2020.02.025

Figure 2: 40 y/o male with 2 separate biopsies for a mass suspicious for low-grade glioma.

Figure 2:

The suspected low-grade glioma appears as a (A) T2W hyperintense, expansile mass in the left insular region with (B) no appreciable enhancing focus,. (C, D) On DSC-MRI rCBV maps that have been thresholded and color-coded, pink regions indicate high rCBV above 2.5. Green indicates low rCBV below 1.0, and Blue indicates moderate rCBV between 1 to 2.5. Two separate biopsies were taken from the patient’s tumor. Biopsy #1 within the lesion (C) was taken from a moderate rCBV region (blue) and yielded low grade (Grade 2) Oligodendroglioma on histopathology. Biopsy #2, from a high rCBV region (pink), revealed a high-grade (Grade 3) component with MIB-1 of 19%, consistent with elevated proliferative indices. The rCBV threshold of 2.5 remains consistent with the study by Maia et al. (reference #15) to separate high- vs. low-grade oligodendrogliomas.