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. 2020 Mar 31;10:5716. doi: 10.1038/s41598-020-61730-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of human TRAM-encoding adenovirus in Rhesus macaques. Three groups of six Rhesus macaques were immunized with ChAd63-ME TRAP alone (a), or mixed with 5x ChAd63-hTRAM (b), or with 5x ChAd63-PfAMA1 (c), at weeks 0 and 8. The individual TRAP-specific IFNγ responses were measured by ELISPOT at several time points as indicated. Each line represents one animal. TRAP specific IFN-γ production was measured after adenovirus vaccination (data not shown) and one week post MVA boost by intracellular cytokine staining. Graphs represent the frequency of IFN-γ⁺ CD4⁺ T cells (d) or IFN-γ⁺ CD8⁺ T cells (e) in each group with each animal displayed as a single point and lines representing the median group response. Antibodies to TRAP were measured by LIPs with the graphs representing the fold increase in TRAP responses between the pre-vaccination timepoint and 4 weeks post adenovirus prime (f) and 3 weeks post-MVA boost (g). Each animal is represented by a single point with lines representing the median response per group.