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. 2020 Feb 6;122(7):1005–1013. doi: 10.1038/s41416-020-0743-8

Fig. 5. Ibrutinib enhances T cell proliferation and effector function of CTLs in vivo.

Fig. 5

Splenocytes were harvested from the vehicle and ibrutinib-treated mice; stained with CD3, CD4, and CD8; and analysed for IL-2, IFN-γ, TNF-α, and Granzyme B production by intracellular flow cytometry. a Expression and e mean fluorescence intensity (MFI) of IL-2, b expression and f MFI of IFN-γ, c expression and g MFI of TNF-α, d expression and h MFI of Granzyme B of CD8+ T cells from splenocytes of vehicle- and ibrutinib-treated mice. Error bars represent means ± SEM. Data are representative of 1 of the 3 independent experiments, with 10–12 mice/group. *P < 0.05, and ***P < 0.0001, by unpaired t test.