Table 1.
Indicators of test performance of gFOBT vs. FIT.
| Type of stool test used for screening | Differencea | ||||
|---|---|---|---|---|---|
| gFOBT Total N = 94,290 | FIT Total N = 28,217 | ||||
| n | % (95% CI) | n | % (95% CI) | % (95% CI) | |
| Positive gFOBT/FIT results | 5645 | 6.0 (5.8–6.1) | 2185 | 7.7 (7.4–8.1) | 1.7 (1.4–2.1) |
| Colonoscopy completion | 4773 | 84.6 (83.6–85.5) | 1716 | 78.5 (76.8–80.3) | −6.1 (−8.0 to −4.1) |
| Detection rate | |||||
| Colorectal cancer | 310 | 0.3 (0.3–0.4) | 119 | 0.4 (0.3–0.5) | 0.1 (0.0–0.2) |
| Advanced adenoma | 410 | 0.4 (0.4–0.5) | 254 | 0.9 (0.8–1.0) | 0.5 (0.3–0.6) |
| Any advanced neoplasm | 720 | 0.8 (0.7–0.8) | 373 | 1.3 (1.2–1.5) | 0.5 (0.4–0.7) |
| Non-advanced adenoma | 868 | 0.9 (0.9–1.0) | 565 | 2.0 (1.8–2.2) | 1.1 (0.9–1.3) |
| Any adenoma | 1278 | 1.4 (1.3–1.4) | 819 | 2.9 (2.7–3.1) | 1.5 (1.3–1.8) |
| Positive predictive valueb | |||||
| Colorectal cancer | 310 | 6.5 (5.8–7.2) | 119 | 6.9 (5.7–8.1) | 0.4 (−1.0 to 1.8) |
| Any advanced neoplasm | 720 | 15.1 (14.1–16.1) | 373 | 21.7 (19.8–23.7) | 6.6 (4.5–8.9) |
CI confidence interval, FIT faecal immunochemical test, gFOBT guaiac-based faecal occult blood test.
aDifferences with a 95% CI completely lower or higher than 0 are statistically significant, which means that the P value does not exceed 0.05.
bPositive predictive value is the percentage of participants with detected neoplasms relative to the number of participants with follow-up colonoscopy completed.