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. 2020 Mar 31;10:5734. doi: 10.1038/s41598-020-62828-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathology of the leopard gecko skin iridophoroma. (a–d) H&E. (e) Nomarski contrast (DIC). (a) Large mass of iridophores in hypodermis (h) and scattered clusters of iridophores in dermis (d), regular collagen fibre arrangements were noted. (b) Infiltration of lymphohistiocytic cells (black arrows) around a skin capillary (black asterisk), atypical oval shaped iridophore with eccentrically located nucleus and brown cytoplasm (white arrow). (c) Tumour cells present both in the epidermis, dermis and hypodermis (h), round and spindle shaped cells filled with guanine crystals (white arrows), regular collagen fibre arrangement. (d) Overview of the affected skin with a tumour lesion (black arrow) and healthy margin without iridophores and other chromatophores (black asterisk). (e) Nomarski contrast used to confirm the presence of iridophores in the skin sections; note the characteristic change in colour of light-reflecting cells (white arrow).