Table 3.
Population secondary pharmacokinetic parameters.
| Day | Dose (mg) | AUC0–4 (h*ng/mL) | AUC0–24 (h*ng/mL) | Cmax (ng/mL) | tmax (h) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Standard deviation | Mean | Standard deviation | Mean | Standard deviation | Median | Range | ||
| NCA and observation | |||||||||
| 1 | 1 | 14.22 | 7.87 | NE | NE | 6.54 | 3.82 | 4.067 | 2.05–7.67 |
| 15 | 1 | 184.33 | 98.14 | NE | NE | 58.67 | 36.84 | 2.05 | 2.00–4.12 |
| Model prediction | |||||||||
| 1 | 1 | 14.28 | 7.66 | 175.98 | 74.29 | 8.75 | 3.27 | 13.33 | 9.63–23.97 |
| 15 | 1 | 190.06 | 90.79 | 1104.89 | 589.09 | 50.67 | 23.35 | 7.00 | 5.97–17.93 |
NCA non-compartmental analysis, AUC0–4 and AUC0–24 area under the concentration–time curve from 0 to 4 and 0 to 24 h, respectively, NE not estimated.