Table 2.
Categories of cancer types according to oncologic risk (recurrence, progression) of hormone replacement therapy
| HRT: | Adavantageous | Neutral (no known negative effect) | Negative effect in certain setting (relative contraindication) | Disadvantageous (contraindicated) |
|---|---|---|---|---|
| Breast cancer | BRCA 1/2 mutation without breast cancer | Breast cancer | ||
| Gynecologic cancers | Endometrial cancer (E2 dependent, type I) – E+P advantageous, E-only: neutral |
• Endometrial cancer (E2 independent, type II) • Uterinal carcinosarcoma • Uterinal adenosarcoma |
Leiomyosarcoma | Endometrial stroma sarcoma |
| Ovarian cancer (epithelial, germ cell tumour) |
Some ovarian tumours: • endometrioid ovarian cancer (?) • granulosa cell tumour |
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| Cervical adenocarcinoma (E+P) | Cervical cancer (squamous cell) | |||
|
Vaginal cancer (squamous cell) (adenocarcinoma??) |
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|
Vulvar cancer (squamous cell) (adenocarcinoma??) |
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| Non-gynecologic cancers | Haematologic malignancies (leukaemias, lymphomas) |
• Microprolactinoma • Macroprolactinoma (?? – close follow-up required if on HRT) |
Brain tumours |
• Meningioma • Glioma |
| Malignant melanoma (local, cutaneous) | Malignant melanoma (advanced, metastatic) | |||
| Colorectal cancer | Lung cancer | |||
| Liver (hepatocellular) cancer | Kidney cancer | Gastric cancer | Gastric cancer (ER+, PR+) | |
| Thyroid cancer | Bladder cancer | Bladder cancer (ER+) | ||
| Pancreatic cancer |