Table 5.
Multivariate analysis of the genetic variants, clinical parameters and lack of treatment response.
| Analysis | Variable | Lack of treatment response | Lack of treatment response risk OR (±95% CI) | P | |
|---|---|---|---|---|---|
| no n (%) | yes n (%) | ||||
| Response | ALDH5A1 rs1054899 | ||||
| CC | 137 (53.5) | 15 (34.1) | 1 (ref.) | ||
| CA/AA | 119 (46.5) | 29 (65.9) | 2.74 (1.25–6.02) | 0.012 | |
| Surgery | |||||
| Yes | 236 (90.4) | 21 (47.7) | 1 (ref.) | ||
| No | 25 (9.6) | 23 (52.6) | 9.95 (4.54–21.80) | <0.00001 | |
| PR status | |||||
| Positive | 149 (60.6) | 14 (33.3) | 1 (ref.) | ||
| Negative | 97 (39.4) | 28 (66.7) | 2.49 (1.16–5.34) | 0.018 | |
OR- odds ratio; 95%CI- confidence interval; bolded numbers indicate results with p < 0.05; PR- progesterone receptor.