Table 6.
The association between accumulations of unfavorable genetic variant and clinical parameters.
| Unfavorable genotypes and clinical factors | Number of unfavorable factors | Lack of treatment response | Logistic Regression | Treatment Failure Free Survival (TFFS) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| no n (%) | yes n (%) | Lack of treatment response risk OR (±95% CI) | P | median survival (months) | log rank p | Event* risk HR (±95% CI) | p | |||
|
ALDH5A1 rs1054899 surgery PGR status |
CA/AA no negative |
0 | 74 (30.7) | 3 (7.1) | 1 (ref. | 82.59 | <0.00001 | 1 (ref. | ||
| 1 | 104 (43.2) | 11 (26.2) | 2.61 (0.91–9.76) | 0.152 | 85.44 | 2.46 (0.69–8.84) | 0.167 | |||
| 2 | 61 (25.3) | 17 (40.5) | 6.87 (1.90–24.81) | 0.003 | 37.59 | 6.55 (1.92–22.38) | 0.003 | |||
| 3 | 2 (0.8) | 11 (26.2) | 135.67 (19.80–929.78) | <0.00001 | 5.67 | 54.17 (14.74–199.14) | <0.00001 | |||
| 0–2 | 239 (99.2) | 31 (73.8) | 1 (ref.) | 79.44 | <0.00001 | 1 (ref.) | ||||
| 3 | 2 (0.8) | 11 (26.2) | 42.40 (8.92–201.64) | <0.00001 | 5.67 | 17.08 (8.26–35.36) | <0.00001 | |||
| 0–1 | 178 (73.9) | 14 (33.3) | 1 (ref.) | 83.51 | <0.00001 | 1 (ref.) | ||||
| 2–3 | 63 (26.1) | 28 (66.7) | 5.65 (2.79–11.45) | <0.00001 | 25.84 | 5.20 (2.78–9.91) | <0.00001 | |||
Lack of treatment response risk and survival of patients defined as the median TFFS survival expressed in months. OR- odds ratio; 95%CI- confidence interval; HR- hazard ratio; * event- death. progression. recurrence and/or secondary metachronous breast cancer.