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. 2020 Mar 31;11(3):211. doi: 10.1038/s41419-020-2404-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, c IHC staining for CTR1 or LOX and Masson’s staining in kidney sections from 10 renal puncture patients. Original magnification, ×200. Bar = 50 μm. b, d Scatter plots with linear regression showing the correlation between CTR1 expression levels and the extent of renal fibrosis (R² = 0.6795, P = 0.0034) and the correlation between LOX expression levels and the extent of renal fibrosis (R² = 0.8193 P = 0.003). The expression of CTR1 and LOX and the level of fibrosis were quantitatively assessed by IHC staining and Masson’s staining, respectively, using a quantitative image-analysis system. Tubulointerstitial fibrosis and LOX and CTR1 expression were quantified based on five randomly selected high-power fields under a microscope equipped with a quantitative image-analysis system (Image-Pro Plus 6.5, Media Cybernetics, Silver Springs, MD), and the results are presented as the percentage of the area with positive staining.