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. 2019 Dec 18;267(4):1070–1079. doi: 10.1007/s00415-019-09671-9

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Responder analysis: percentage of patients with better or same Norfolk QOL-DN Scores at week 66 relative to baseline by treatment arm. ADL activities of daily living, QOL Quality of Life, PF physical functioning. Better/same scores defined as less than 0.5 of a standard deviation higher at week 66 than at baseline *p < 0.05, ^†p < 0.01, ^‡p < 0.001