FIGURE 1.

Acid production from glucose by S. wiggsiae and inhibitory effects of fluoride on such acid production. (A) Curves of the reduction in pH from pH 7.0; (B) the rates of acid production at pH 7.0 and 5.5. The data are shown as the mean and standard deviation of three independent experiments. Fifty percent inhibitory concentrations (IC₅₀) were calculated from the fluoride concentration and the rate of acid production. The significance of difference from the control was analyzed using Dunn’s test (*P < 0.05).