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. 2020 Mar 25;14:10. doi: 10.3389/fncir.2020.00010

Figure 4.

Figure 4

Cell body inhibition of NAc afferents reveals pathway-specific contributions of PVT and BLA inputs to reward-seeking. (A) Schematic of viral injections and optic probe placements (left). Representative coronal brain slices showing ArchT-GFP expression in axon terminals in the NAc (middle) and in soma that project to the NAc in the PVT and BLA (right). Scale bar, 500 μm. (B,C) Photoinhibition of NAc-projecting PVT neurons increases active lever responses (nGFP = 8; nPVT = 7; nBLA = 8; F(2,20) = 8.31, p < 0.01, tPVT(20) = 4.68*) and food port entries (F(2,20) = 3.76, p < 0.05; tPVT(20) = 3.47*). (D) During extinction, photoinhibition of NAc-projecting BLA neurons increases inactive lever responses (F(2,20) = 4.32, p < 0.05; tBLA(20) = 3.44*). Error bars represent SEM. *Signifies p < 0.05. 3V, third ventricle; ac, anterior commissure; BLA, basolateral amygdala; BMP, posterior basomedial amygdaloid nucleus; CM, central medial thalamic nucleus; HPC, hippocampus; LA, lateral amygdaloid nucleus; MD, mediodorsal thalamic nucleus; PV, paraventricular thalamic nucleus.