Table 2.
Genes and their single nucleotide polymorphisms investigated in association with new-onset of diabetes mellitus after liver transplantation
| Ref. |
Etiology/Population |
Genes and best 95%CI OR | Key points |
| N (non-NODM/NODM) | |||
| Mottaghi et al[31] | Various | Recipient AGT: rs699 - 7.326 (2.0-26.8), rs4762 – NS | The presence of AGT rs699 T allele may significantly increase the NODM risk |
| Iran | |||
| 62/53 | |||
| Husen et al[25] | Various | Recipient Mtor: rs2295080 (1.48-23.4); rs12139042, rs2536 – NS | rs2295080 CC genotype is associated with a risk of DM on everolimus-based IS |
| European | |||
| 115/121 | DM was a secondary objective, with a very low N of DM patients | ||
| Cen et al[26] | Hepatitis C, HCC | Recipient ADIPOQ: rs1501299 (0.05-0.61)2, rs822396 (0.13-0.70)3; NS for recipient SNPs: ADIPOR2 rs767870, TLR4 rs1927907, CCL5 rs2107538 and rs2280789, CYP3A5 rs776746, PPARA rs4823613, ACE rs4291, HSD11B1 rs4844880, KCNJ11 rs5219, KCNQ1 rs2237892 | ADIPOQ rs1501299 and rs822396 are associated with a risk of NODM |
| China | |||
| 181/75 | rs1501299 is an independent risk factor | ||
| Zhang et al[28] | Various | Recipients SUMO4: rs237025 (1.42-5.91); Donors SUMO4: rs237025 (1.542–9.007) | Donor and recipient rs237025 G allele and their combination were independent predictive factors for NODM |
| China | |||
| 102/24 |
In the cited article the N of non-diabetic patients is wrongly stated to be 127, which is a total N.
Calculated from study data for codominant model by authors of this review.
Calculated from study data for dominant model by authors of this review. ACE: Angiotensin I converting enzyme; ADIPOQ: Adiponectin, C1Q and collagen domain containing; ADIPOR2: Adiponectin receptor 2; AGT: Angiotensinogen; CCL5: Chemokine (C-C motif) ligand 5; CYP: Cytochrome P450; DM: Diabetes mellitus; HCC: Hepatocellular carcinoma; HSD11B1: Hydroxysteroid 11-beta dehydrogenase 1; IS: Immunosuppression; KCNJ11: Potassium inwardly-rectifying channel, subfamily J, member 11; KCNQ1: Potassium voltage-gated channel, KQT: Like subfamily, member 1; mTOR: Mammalian target of rapamycin; N: Number; NODM: New-onset diabetes mellitus; NS: Not significant; PPARA: Peroxisome proliferator-activated receptor alpha; SNP: Single nucleotide polymorphism; SUMO4: Small ubiquitin like modifier 4; TLR4: Toll like receptor 4; 95%CI OR: 95% confidence interval for odds ratio.