Table 4.
Biochemical characteristics between patients with the rs1055348 G allele and those without the rs1055348 G allele
| Variables |
PM-DILI |
Other-DILI |
|||||
| With the rs1055348 G allele (n = 58) | Without the rs1055348 G allele (n = 15) | P value | With the rs1055348 G allele (n = 32) | Without the rs1055348 G allele (n = 86) | P value | ||
| Age, mean ± SD, yr | 46.7 ± 15.1 | 51.2 ± 16.2 | 0.317 | 49.2 ± 14.4 | 53.4 ± 14.0 | 0.152 | |
| Female, n (%) | 42 (72.4) | 14 (93.3) | 0.167 | 22 (68.8) | 52 (60.5) | 0.408 | |
| BMI | 23.7 ± 2.9 | 23.0 ± 3.0 | 0.407 | 23.8 ± 3.0 | 24.0 ± 3.9 | 0.774 | |
| Medication time1, d | 30 (40.8) | 30 (22) | 0.533 | 46.5 (63.5) | 30 (54) | 0.269 | |
| ALT (U/L) | 1234.8 ± 609.5 | 603.2 ± 517.0 | < 0.0001 | 936.7 ± 866.7 | 510.8 ± 532.7 | 0.013 | |
| AST (U/L), n | 876.9 ± 537.8 (51) | 509.2 ± 507.6 (14) | 0.025 | 712.8 ± 691.5 (32) | 401.0 ± 513.4 (86) | 0.009 | |
| ALP (U/L), n | 155.8 ± 59.8 (48) | 116.7 ± 40.0 (11) | 0.044 | 140.3 ± 99.4 (28) | 167.8 ± 240.8 (77) | 0.559 | |
| TBil (mg/dL), n | 123.9 ± 110.5 (48) | 70.7 ± 84.9 (13) | 0.113 | 85.7 ± 104.8 (29) | 73.3 ± 87.4 (70) | 0.547 | |
1
A variable is expressed as the median (interquartile range). Variables are expressed as the mean ± SD. PM-DILI: Polygonum multiflorum-induced liver injury; Other-DILI: Other drug-induced liver injury; BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; Tbil: Total bilirubin level.