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. 2020 Mar 25;10:388. doi: 10.3389/fonc.2020.00388

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Copyright © 2020 Blanquart, Jaurand and Jean.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo models of malignant mesothelioma (MM) in asbestos-treated rodents and genetically modified mice (GEM). MM can be obtained from wild type (WT) rats or mice, exposed to asbestos, or GEM. Asbestos-induced MM models are generated by the injection of asbestos fibers intracavitary, in the pleura or peritoneum, mostly peritoneal in mice. Conditional mutant mice are obtained by engineering the major genes altered in MM. Asbestos-recipient animals and GEM may be investigated for tumor incidence, survival, quantitative and qualitative analyses of cells in ascites or pleural fluid, and molecular alterations in tumors.