TABLE 5.
Distribution of genotypes and alleles of the three loci in the control group and the significant myopic shift group.
| SNP | SNP model | OR (95% CI) | P | P′ | ||||
| AREG | ||||||||
| rs12511037 | CC | CT | TT | C/T | 1.037 (0.763–1.408) | |||
| △SER > −0.50 D/y | 112 (0.310) | 100 (0.277) | 149 (0.413) | 0.449/0.551 | Dominant | 0.681 | 0.679 | |
| △SER ≤ −0.50 D/y | 35 (0.324) | 25 (0.231) | 48 (0.445) | 0.440/0.560 | Recessive | 0.656 | 0.661 | |
| Heterozygous | 0.347 | 0.35 | ||||||
| Additive | 0.971 | 0.972 | ||||||
| General | 0.642 | 0.647 | ||||||
| GABRR1 | ||||||||
| rs13215566 | CC | CG | GG | C/G | 0.740 (0.159–3.453) | |||
| △SER > −0.50 D/y | 353 (0.978) | 7 (0.019) | 1 (0.003) | 0.988/0.012 | Dominant | 0.758 | 0.754 | |
| △SER ≤ −0.50 D/y | 106 (0.981) | 2 (0.019) | 0 (0) | 0.990/0.009 | Recessive | – | – | |
| Heterozygous | 0.851 | 0.722 | ||||||
| Additive | 0.692 | 0.643 | ||||||
| General | 0.824 | 0.976 | ||||||
| PDE10A | ||||||||
| rs12206610 | CC | CT | TT | C/T | 1.022 (0.589–1.773) | |||
| △SER > −0.50 D/y | 302 (0.837) | 59 (0.163) | 0 (0) | 0.918/0.082 | Dominant | 0.982 | 0.99 | |
| △SER ≤ −0.50 D/y | 90 (0.833) | 18 (0.167) | 0 (0) | 0.917/0.083 | Recessive | – | – | |
| Heterozygous | 0.982 | 0.99 | ||||||
| Additive | 0.982 | 0.99 | ||||||
| General | − | − |
SER, spherical equivalent refraction; ΔSER, annual shift in refraction; OR, odds ratio; CI, confidence interval; P, P-value; P′, p value adjusted by 10,000 permutations. A significant myopic shift was defined as ΔSER ≤ −0.50 D/y. Adjusted for sex, age, near-work time, and outdoor time.