Table 3.
Persistent inward current characteristics (16 s ramp).
| Variable | Condition | Mean | SD | N | p |
|---|---|---|---|---|---|
| Norm PIC amp (pA/pF) | Sham | −2.32 | 2.77 | 6 | |
| HI Unaffected | −1.58 | 0.90 | 13 | 0.953 | |
| HI Mild | −1.73 | 0.94 | 9 | 0.706 | |
| HI Severe | −1.03 | 0.50 | 8 | 0.735 | |
| PIC onset (mV) | Sham | −47.2 | 6.0 | 6 | |
| HI Unaffected | −39.7 | 6.3 | 13 | 0.086 | |
| HI Mild | −40.9 | 9.7 | 9 | 0.169 | |
| HI Severe | −35.0 | 11.5 | 8 | 0.013* | |
| PIC max (mV) | Sham | −27.8 | 9.4 | 6 | |
| HI Unaffected | −21.4 | 7.4 | 13 | 0.175 | |
| HI Mild | −24.2 | 9.9 | 9 | 0.479 | |
| HI Severe | −18.3 | 11.1 | 8 | 0.071 | |
| PIC negative slope range (mV) | Sham | 19.5 | 6.0 | 6 | |
| HI Unaffected | 18.3 | 3.2 | 13 | 0.927 | |
| HI Mild | 16.6 | 2.4 | 9 | 1.000 | |
| HI Severe | 16.7 | 4.1 | 8 | 0.872 | |
| PIC amplitude (pA) | Sham | −315 | 189 | 6 | |
| HI Unaffected | −389 | 227 | 13 | 0.215 | |
| HI Mild | −397 | 254 | 9 | 0.310 | |
| HI Severe | −323 | 113 | 8 | 0.802 |
*Significant difference to sham animals.