Figure 4.

hCB2-Mediated inhibition of cAMP production in response to forskolin (Fsk) and drug combinations with 10 µM myrcene (A), α-pinene (B), β-pinene (C), β-caryophyllene (D), limonene (E), or terpene mixtures (F). Figure (G) shows inhibition of the Fsk response by an approx. EC50 concentration of THC (30 nM) in combination with 10 µM of each of the five terpenes. Data are normalized to forskolin (100%) and basal (0%). cAMP responses were stimulated with forskolin (5 µM), and all cannabinoids and terpenes were at a final concentration of 10 µM. Data are means ± SEM of three independent determinations.