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. 2020 Mar 25;11:288. doi: 10.3389/fphar.2020.00288

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Copyright © 2020 Balkrishna, Sakat, Ranjan, Joshi, Shukla, Joshi, Verma, Gupta, Bhattacharya and Varshney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In-vitro analysis of cellular and biochemical effects of Divya Sarva-Kalp-Kwath (SKK): (A) significant loss of cell viability was observed following the stimulation of HepG2 cells with 10 mM of CCl₄. Co-treatment of the CCl₄ stimulated HepG2 cells with SKK led to a significant recovery of cell viability. Also, CCl₄ stimulation of the HepG2 cells led to an augmented release of liver injury serum-based biomarkers, (B) aspartate aminotransferase (AST), and (C) alkaline phosphatase (ALP). Release of these serum hepatotoxicity biomarkers was ameliorated following co-treatment of the CCl₄ stimulated HepG2 cells with SKK (0.5 and 1 mg/mL). Results are expressed as mean ± standard deviation. One-way analysis of variance (ANOVA) followed by Dunnett's multiple comparison t-test was used to calculate the statistical difference. p-value *<0.05; **<0.01; ^#<0.01.