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. 2020 Feb 20;4(4):527–539. doi: 10.1002/hep4.1487

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© 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Human CES1 reduces alcohol‐induced apoptosis and ROS formation. C57BL/6 mice were fed a control diet or alcohol as described in Fig. 4 (n = 8 per group). (A) Representative images of TUNEL staining. (B) Hepatic apoptotic cells (percentage). (C) Hepatic MDA levels. (D) Hepatic 2',7'‐dichlorodihydrofluorescein levels. Hepatic proteins were detected by western blot assays (E), and hepatic phosphorylated versus total Smad2/3 (P/T‐Smad2/3) levels (F) and CASP3 levels (G) were determined. *P < 0.05, **P < 0.01. Abbreviation: DCF, 2',7'‐dichlorodihydrofluorescein.