Table 1.
Fatty Acids | Control Diet | Control Diet | EtOH Diet | EtOH Diet |
---|---|---|---|---|
AAV‐Null | AAV‐hCES1 | AAV‐Null | AAV‐hCES1 | |
C14:0 | 0.128 ± 0.02 | 0.106 ± 0.017 | 0.308 ± 0.09‡ | 0.121 ± 0.02§ |
C16:0 | 21.93 ± 3.36 | 37.49 ± 10.17 | 48.38 ± 4.98‡ | 34.26 ± 2.73§ |
C16:1 | 0.338 ± 0.05 | 0.366 ± 0.06 | 0.768 ± 0.205 | 0.178 ± 0.037|| |
C18:0 | 7.68 ± 0.31 | 6.2 ± 0.35*, † | 12.85 ± 1.13*, † | 8.41 ± 0.38|| |
C18:1 | 25.27 ± 3.63 | 27.36 ± 3.22 | 61.71 ± 10.41*, † | 42.77 ± 0.65 |
C18:2 | 11.64 ± 1.85 | 10.7 ± 1.26 | 43.36 ± 5.85‡ | 27.31 ± 1.78§ |
C20:4 | 0.53 ± 0.15 | 0.146 ± 0.04*, † | 0.225 ± 0.05*, † | 0.023 ± 0.007|| |
C22:6 | 7.99 ± 2.26 | 2.57 ± 0.51*, † | 3.34 ± 0.776*, † | 0.912 ± 0.05§ |
C57BL/6 mice were injected with AAV8‐ALB‐Null or AAV8‐ALB‐hCES1 and fed a control diet or EtOH diet. Hepatic fatty acid composition was analyzed by GC‐MS.
P < 0.05 versus control diet–fed AAV‐Null group.
P < 0.05.
P < 0.01 versus control diet–fed AAV‐Null group.
P < 0.05.
P < 0.01 versus EtOH diet–fed AAV‐Null group.