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Biotechnological applications of IgG-specific endoglycosidases. Specific hydrolysis of IgG Fc glycans by endoglycosidases offers new possibilities for many different applications, such as glycan remodeling by transglycosylation (A), as a way to achieve homogeneous, site-specific antibody conjugates (B), to increase specificity in imaging assays (C), to abolish ADCC for mAb mode-of-action studies (D), to simplify analytics of mAbs (E) or for simplified assays for serum IgG analysis (F).
