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O-glycosylation of immunoglobulin G and Ig-fusion proteins. Schematic representation of O- and N-linked glycosylation pattern of human immunoglobulin (Ig) G3 (A) and the TNFαRII–IgG-Fc fusion protein etanercept (B). Both glycoproteins have several possible O-glycosylation sites, as well as N-glycan(s).
