Table 3.
Top canonical pathways associated with LX-2 activation.
| Pathway | # mol/totala | p-valueb | Molecules |
|---|---|---|---|
| Hepatic fibrosis | 54/186 | 1.35E-16 | TGFBR1, IL6, IL1R2, VEGFA, TGFB1, LAMA1, MYL4, SERPINE1, IL1RAP, TNFRSF11B, CXCL8, COL4A1, COL2A1, VEGFC, IGFBP5, MMP2, COL21A1, COL6A3, COL13A1, ACTA2, IGFBP3, CD14, AGTR1, COL3A1, IL1A, ICAM1, COL4A5, FN1, COL4A6, FGF2, COL4A3, EGF, CCL5, COL4A2, COL15A1, PGF, COL1A2, COL16A1, CCL2, EDN1, TIMP1, TGFB2, LBP, MMP1, EGFR, IL4, COL6A2, EDNRB, COL12A1, IL1R1, FGF1, IL1B, COL9A2, MMP9 |
| Osteoarthritis | 55/212 | 1.47E-14 | TGFBR1, RARRES2, MMP3, PTHLH, IL1R2, VEGFA, ITGA3, TGFB1, CNMD, ADAMTS5, IL1RAP, ADAMTS4, CASP10, ITGA4, CXCL8, DDIT4, DCN, COL2A1, ITGA5, VEGFC, TCF3, NKX3-2, S1PR3, TLR2, FZD5, HTRA1, JAG1, CASP5, TCF4, FN1, FRZB, FGF2, CASP4, HIF1A, PGF, GLIS1, PRKAA2, CASP1, CASP8, MMP1, TIMP3, EPAS1, ITGA2, GREM1, TCF7L1, IL1R1, CEBPB, WNT3A, PTH1R, IL1B, WISP1, PTGS2, GLI1, P2RX7, MMP9 |
| Axonal guidance signaling | 83/501 | 1.09E-09 | GAB2, ADAMTS8, MYL10, WNT3, MMP3, PIK3R1, MMP16, CXCL12, ADAM11, ADAMTS2, VEGFA, ITGA3, EPHB1, PLCE1, SEMA3D, MAPK3, PIK3CG, ABLIM3, MYL4, PLCB1, IRS2, FRS2, ADAMTS5, ADAMTS4, ITGA4, PAPPA, NGEF, FES, ITGA5, VEGFC, L1CAM, MMP2, PLCL2, ADAMTS9, PIK3R3, ADAMTS6, ADAM12, ARHGEF6, PRKCH, PIK3CD, FZD5, EPHA2, GNAL, NRP1, MME, ERAP2, MMP7, NTF3, RGS3, BMP3, EGF, ADAM33, EPHA4, PLXNA2, NGF, PGF, EFNB2, GLIS1, RHOD, SDC2, ADAM19, TUBA3C/TUBA3D, SEMA3B, RASSF5, PLCD4, MMP1, UNC5C, ADAMTS15, EPHB4, PLXNC1, ITGA2, SLIT2, ROBO3, PLXND1, SEMA3A, WNT3A, NTRK3, EPHA5, SEMA3C, SEMA4B, GLI1, MMP9, WNT5A |
| Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis | 60/327 | 4.86E-09 | SOCS1, GAB2, MMP3, WNT3, PIK3R1, CXCL12, IL6, CCND1, IL18R1, IL1R2, VEGFA, CAMK2D, PLCE1, TGFB1, MAPK3, PIK3CG, PLCB1, IRS2, IL1RAP, FRS2, PRSS3, ADAMTS4, TNFRSF11B, CXCL8, VEGFC, PLCL2, IL37, TCF3, IL7, TLR2, PIK3R3, FZD5, PIK3CD, PRKCH, TCF4, IL1A, ICAM1, FN1, FRZB, FGF2, CEBPD, CCL5, PGF, IRAK1, CCL2, TLR3, PLCD4, MMP1, MAP2K7, MYD88, IL15, DAAM1, IKBKE, IL1R1, TCF7L1, CEBPB, PRSS1, WNT3A, IL1B, WNT5A |
| Cardiac hypertrophy signaling | 80/498 | 9.0E-09 | GAB2, MAP3K15, LIF, TGFBR1, WNT3, TGFBR3, PIK3R1, PDE3A, IL6, IL18R1, IL1R2, ITGA3, PLCE1, PDE6A, CAMK2D, PDE7B, TGFB1, MAPK3, PIK3CG, PLCB1, IRS2, FRS2, ITGA4, IL2RB, TNFRSF11B, FGF19, CXCL8, PDE2A, ITGA5, PLCL2, IL37, PDE4B, ITPR1, PDE1C, PIK3R3, ADRA2A, CD70, ITPR3, IFNLR1, PRKCH, PIK3CD, FZD5, AGTR1, TG, FGF5, IL1A, IL17RD, FGF2, IL22RA1, MAP3K5, PDE1A, FGF13, IL17B, HAND2, ADRB1, EDN1, TGFB2, PDE4D, IL27RA, PLCD4, ACVR1C, IL4, MAP2K7, EDNRB, PDE9A, IL15, ITGA2, RPS6KA5, IKBKE, IL1R1, FGF1, NPPB, PRKG1, WNT3A, MYOCD, PDE5A, IL1B, FGF20, PTGS2, WNT5A |
| Sperm motility | 44/225 | 8.08E-08 | TYRO3, PLA2R1, LMTK3, EPHA4, PDE1A, STYK1, EPHB1, PLCE1, TXK, PLA2G5, PLCB1, KIT, PDE4D, PLCD4, EGFR, PDE2A, EPHB4, MAP2K7, FES, PLA2G4C, PLA2G1B, PLCL2, ITPR1, PDE4B, ROR1, AXL, FRK, CNGA1, DDR1, PDE1C, NPPB, TEC, PLA2G4A, PRKG1, ABL2, FLT3LG, NTRK3, ITPR3, EPHA5, RARRES3, PRKCH, EPHA2, CATSPER1, PAFAH1B3 |
| Bladder cancer signaling | 25/97 | 2.49E-07 | MMP7, MMP3, FGF2, SUV39H1, MMP16, EGF, CCND1, FGF13, PGF, VEGFA, MAPK3, MMP1, FGF19, EGFR, MMP19, CXCL8, DAPK1, VEGFC, MMP2, RPS6KA5, FGF1, CDKN1A, FGF20, MMP9, FGF5 |
| Regulation of EMT | 39/201 | 5.32E-07 | GAB2, TCF4, SNAI2, TGFBR1, WNT3, FGF2, PIK3R1, PARD6B, EGF, HIF1A, PARD6A, SMURF1, FGF13, MAML1, TGFB1, PIK3CG, MAPK3, TGFB2, IRS2, FRS2, EGFR, FGF19, MAP2K7, ESRP2, MMP2, TCF7L1, TCF3, FGF1, PIK3R3, GSC, WNT3A, CDH12, FGF20, FZD5, PIK3CD, JAG1, MMP9, FGF5, WNT5A |
a
number of genes identified in dataset/total number participating in pathway.
b
calculated using Fisher's exact test.