Fig. 2.

Phenotype and frequencies of cytokine-producing CD4⁺ T cells in response to SEB and TT of the patient with 22q11.2DDS two weeks after TT vaccination, in comparison with T cells from a healthy control. A Left dot plots show frequencies of live CD3⁺CD4⁺ T cells expressing CD45RA and CCR7. Middle and right dot plots represent frequencies of live CD3⁺CD4⁺ T cells producing IFNγ and TNFα (with the expression of IL-2 being represented for each event by the color bar on the right) after stimulation with control medium or TT. B Boolean analysis of CD4⁺ T cells that produce IL-2, IFN-γ, or TNF-α, individually or in combination, after stimulation with medium, SEB, and TT in the control volunteer (top) and patient (bottom).